LY379268
Cat. No.：YN322361
| 产品名称: | LY379268 |
| CAS No.: | 191471-52-0 |
| Chemical Name: | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Synonyms: | LY-379268,LY 379268 |
| 分子量: | 187.2 |
| 分子式: | C7H9NO5 |
| SMILES: | [H][C@]1([C@@H]2C(O)=O)[C@]2([H])[C@@](C(O)=O)(N)CO1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY379268 是一种有效、选择性和可透过血脑屏障的mGlu2/3R激动剂，EC50值为 2.69 nM (mGlu2) 和 4.48 nM (mGlu3)。LY379268 对人 mGlu 1a、4a、5a 或 7a 受体没有活性。LY379268 具有抗氧化和神经保护作用。 |
| IC50和靶点: | [{name:"hmGluR2:2.69 nM (EC50)"},{name: "hmGluR3:4.48 nM (EC50)"},{name: "hmGluR2:14.1 nM (Ki)"},{name: "hmGluR3:5.8 nM (Ki)"}] |
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Monn, J.A., Valli, M.J., Massey, S.M., et al.Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): Identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptorsJ. Med. Chem.42(6),1027-1040(1999)
Wang, M.-J., Li, Y.-C., Snyder, M.A., et al.Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neuronsPLoS One8(4),e61787(2013)
Bond, A.D., Jones, N.M., Hicks, C.A., et al.Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivoJ. Pharmacol. Exp. Ther.294(3),800-809(2000)
Cartmell, J., Perry, K.W., Salhoff, C.R., et al.The potent, selective mGlu2/3 receptor agonist LY379268 increases extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole-3-acetic acid in the medial prefrontal cortex of the freely moving ratJ. Neurochem.75(3),1147-1154(2000)
