CCG-232601
Cat. No.：YN322363
| 产品名称: | CCG-232601 |
| CAS No.: | 1922099-21-5 |
| Chemical Name: | N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-3-piperidinecarboxamide |
| Synonyms: | CCG232601 |
| 分子量: | 455.8841264 |
| 分子式: | C24H20ClF2N3O2 |
| SMILES: | O=C(N1CC(F)(F)CC(C(NC2=CC=C(Cl)C=C2)=O)C1)C3=CC(C4=CC=NC=C4)=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCG-232601 (compound 8f) 是一种有效的具有口服活性的Rho/MRTF/SRF转录通路抑制剂。CCG-232601 抑制博来霉素诱导的小鼠皮肤纤维化的发展。CCG-232601 具有研究系统性硬皮病抗纤维化的潜力。 |
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Hutchings, K.M., Lisabeth, E.M., Rajeswaran, W., et al.Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic sclerodermaBioorg. Med. Chem. Lett.27(8),1744-1749(2017)
