ULS 欢迎您!
ULS 欢迎您!
> 产品中心 > 抑制剂 & 激动剂 > GPCR/G Protein > 5-HT Receptor

SC-19220

Cat. No.:YN322367

  • CAS No. :19395-87-0

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: SC-19220
      CAS No.: 19395-87-0
      Chemical Name: 8-chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxy-(2-acetyl)hydrazide
      Synonyms:
      分子量:331.8
      分子式:C16H14ClN3O3
      SMILES:CC(=O)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc12
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: SC-19220 是一种竞争性prostaglandinn E2受体拮抗剂。SC-19220 增加了尿烷麻醉大鼠的膀胱容量并降低了排尿(由缓慢的经膀胱充盈引起)的排尿效率。SC-19220 可恢复烧伤脓毒症后骨髓粒细胞和单核细胞生成的平衡。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Coleman, R.A., Eglen, R.M., Jones, R.L., et al.Classification of prostanoid receptors IUPHAR receptor compendiumIUPHAR Compendium,1-12(1997)

      Zeng, L., An, S., and Goetzl, E.J.Selective regulation of RNK-16 cell matrix metalloproteinases by the EP4 subtype of prostaglandin E2 receptorBiochemistry35,7159-7164(1996)

      Rakovska, A., and Milenov, K.Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2, and F2αArch. Int. Pharmacodyn Ther.268,59-69(1984)

      Sanner, J.Prostaglandin Inhibition with a dibenzoxazepine hydrazide derivative and morphineAnn. N. Y. Acad. Sci.180,396-409(1971)

      Coleman, R.A., and Kennedy, I.Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated tracheaProstaglandins29,363-375(1985)

      Funk, C.D., Furci, L., Fitzgerald, G.A., et al.Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtypeJ. Biol. Chem.268(35),26767-26772(1993)

      Bastien, L., Sawyer, N., Grygorczyk, R., et al.Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtypeJ. Biol. Chem.269(16),11873-11877(1994)

      Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2),217-224(1997)

      Inoue, H., Tsujisawa, T., Fukuizumi, T., et al.SC-19220, a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell culturesJ. Endocrinol.161(2),231-236(1999)

      Ma, X., Kundu, N., Ioffe, O.B., et al.Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparitiesMol. Cancer Res.8(10),1310-1318(2010)

      Carrasco, E., Casper, D., and Werner, P.PGE2 receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE2 neurotoxicityJ. Neurosci. Res.85,3109-3117(2007)

    • 摩尔计算器
    • 稀释计算器
    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    计算

    质量 浓度 体积 分子量
    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
      V1
      C2
      V2
    • 您最近查看的产品:
    相关产品


    ULS 的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)Copyright © 2020-2021 ULS. All Rights Reserved. 备案号:粤ICP备2021013238号-1
    0.375293s