MTEP
Cat. No.：YN322368
| 产品名称: | MTEP |
| CAS No.: | 194918-76-8 |
| Chemical Name: | (4β)--amino-1α,2α,4-cyclopentanetricarboxylic acid |
| Synonyms: | |
| 分子量: | 217.2 |
| 分子式: | C8H11NO6 |
| SMILES: | OC(=O)[C@H]1CC(N)(C[C@H]1C(=O)O)C(=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | rel-ACPT-I 是 group IIImGluRs的激动剂，具有多种生物活性，包括神经保护、抗惊厥和抗焦虑样作用。 |
| IC50和靶点: | |
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Acher, F.C., Tellier, F.J., Azerad, R., et al.Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: New tools to discriminate between metabotropic glutamate receptor subtypesJ. Med. Chem.40,3119-3129(1997)
Domin, H., Przykaza, Ł., Jantas, D., et al.Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studiesNeuropharmacology102,276-294(2016)
Domin, H., Gołenbiowska, K., Jantas, D., et al.Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivoNeurotox. Res.26(1),99-113(2014)
Chapman, A.G., Talebi, A., Yip, P.K., et al.Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acidEur. J. Pharmacol.424(2),107-113(2001)
Stachowicz, K., Kłodzińska, A., Palucha-Poniewiera, A., et al.The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systemsNeuropharmacology57(3),227-234(2009)
