HTMT dimaleate
Cat. No.：YN322370
| 产品名称: | HTMT dimaleate |
| CAS No.: | 195867-54-0 |
| Chemical Name: | 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-N-[4-(trifluoromethyl)phenyl]-heptanamide, 2Z-butenedioate |
| Synonyms: | |
| 分子量: | 614.5676896 |
| 分子式: | C19H25F3N4O • 2C4H4O4 |
| SMILES: | FC(F)(F)C1=CC=C(NC(CCCCC(C)NCCC2=CN=CN2)=O)C=C1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HTMT (dimaleate) 是一种有效的组胺 H1 和 H2 受体激动剂。在自然抑制细胞中，HTMT (dimaleate) 在 H2 受体介导的效应中的活性是组胺的 4 x 104倍。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shayo, C., Fernandez, N., Legnazzi, B.L., et al.Histamine H2 receptor desensitization: Involvement of a select array of G protein-coupled receptor kinasesMol. Pharmacol.60(5),1049-1056(2001)
Zhu, Y., Michalovich, D., Wu, H., et al.Cloning, expression, and pharmacological characterization of a novel human histamine receptorMol. Pharmacol.59(3),434-441(2001)
Qiu, R., Melmon, K.L., and Kahn, M.M.Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytesJ. Pharmacol. Exp. Ther.253(3),1245-1252(1990)
Francis, H., Glaser, S., Demorrow, S., et al.Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathwayAm. J. Physiol. Cell Physiol.295(2),C499-C513(2008)
Tripathi, T., Shahid, M., Khan, H.M., et al.Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonistsPharmacol. Rep.62(5),917-925(2010)
Bell, J.K., McQueen, D.S., and Rees, J.L.Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in BalbC miceBr. J. Pharmacol.142(2),374-380(2004)
