Tesofensine
Cat. No.：YN380363
CAS No. ：195875-84-4
| 产品名称: | Tesofensine |
| CAS No.: | 195875-84-4 |
| Chemical Name: | (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane |
| Synonyms: | NS-2330 |
| 分子量: | 328.27606 |
| 分子式: | C17H23Cl2NO |
| SMILES: | CN1[C@@H]2C[C@H](C3=CC(Cl)=C(Cl)C=C3)[C@@H](COCC)[C@H]1CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tesofensine (NS-2330) 是一种三元单胺再摄取抑制剂，可有效抑制神经递质多巴胺 (DA;IC50=6.5 nM)、去甲肾上腺素 (NE;IC50=1.7 nM) 和血清素 (5-HT;IC50=11 nM) 在突触间隙中的再摄取，并具有作为抗肥胖剂的潜力。Tesofensine 是一种中枢神经系统作用的抗肥胖剂。 |
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Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H.Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese ratNeuropsychopharmacology35(7),1464-1476(2010)
van de Giessen, E., de Bruin, K., la Fleur, S.E., et al.Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese ratsEur. Neuropsychopharmacol.22(4),290-299(2012)
