XAP044
Cat. No.：YN322372
| 产品名称: | XAP044 |
| CAS No.: | 196928-50-4 |
| Chemical Name: | 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one; |
| Synonyms: | XAP044; XAP 044; XAP-044 |
| 分子量: | 380.137 |
| 分子式: | C15H9IO4 |
| SMILES: | O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XAP044 是一种有效的、选择性的mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 (mGlu7) 是哺乳动物 CNS 中神经传递的重要突触前调节剂。XAP044 在啮齿动物行为范式中表现出良好的大脑暴露和广谱抗应激、抗抑郁和抗焦虑药功效。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
(1) Gee, C. et al.: J. Biol. Chem., 289, 10975 (2014) & (2) Tetko, I. et al.: Biorg. Khim., 21, 809 (1995)
