(S)-3,4-DCPG
Cat. No.：YN322380
| 产品名称: | (S)-3,4-DCPG |
| CAS No.: | 201730-11-2 |
| Chemical Name: | 4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid |
| Synonyms: | |
| 分子量: | 239.2 |
| 分子式: | C10H9NO6 |
| SMILES: | O=C(O)C1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-3,4-DCPG 是代谢型谷氨酸受体 8a (mGluR8a) 的选择性激动剂，在表达人类mGluR8的 AV12-664 细胞中其EC50为 31 nM。 |
| IC50和靶点: | [{name:"hmGluR8a:31 nM (EC50)"}] |
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Thomas, N.K., Wright, R.A., Howson, P.A., et al.(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cordNeuropharmacology40(3),311-318(2001)
Reed, B.T., Morgans, C.W., and Duvoisin, R.M.Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compoundsNeuropharmacology67,88-94(2013)
Johnson, K.A., Jones, C.K., Tantawy, M.N., et al.The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's diseaseNeuropharmacology66,187-195(2013)
