D-threo-PDMP
Cat. No.：YN380374
| 产品名称: | D-threo-PDMP |
| CAS No.: | 216758-20-2 |
| Chemical Name: | 2R-(hydroxymethyl)-1-[5-(tricyclo[3.3.2.13,7]dec-1-ylmethoxy)pentyl]-3R,4R,5S-piperidinetriol |
| Synonyms: | AMP-DNM |
| 分子量: | 397.6 |
| 分子式: | C22H39NO5 |
| SMILES: | OC[C@H]1N(CCCCCOCC23CC4CC(CC(C4)C3)C2)C[C@H](O)[C@@H](O)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMP-Deoxynojirimycin (AMP-DNM) 是一种有效的神经酰胺葡萄糖基转移酶 (ceramide glucosyltransferase) 和GCase 2抑制剂。AMP-Deoxynojirimycin 也是一种 GlcCer 生物合成抑制剂。 |
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Bijl, N., Scheij, S., Houten, S., et al.The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cellsJ. Pharmacol. Exp. Ther.326(3),849-855(2008)
Aerts, J.M., Hollak, C., Boot, R., et al.Biochemistry of glycosphingolipid storage disorders: Implications for therapeutic interventionPhilos. Trans. R. Soc. Lond. B Biol. Sci.358(1433),905-914(2003)
Overkleeft, H.S., Renkema, G.H., Neele, J., et al.Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidaseJ. Biol. Chem.273(41),26522-26527(1998)
Shen, C., Bullens, D., Kasran, A., et al.Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitisInt. Immunopharmacol.4(7),939-951(2004)
Aerts, J.M., Ottenhoff, R., Powlson, A.S., et al.Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivityDiabetes56(5),1341-1349(2007)
