Antalarmin hydrochloride
Cat. No.：YN322400
CAS No. ：220953-69-5
| 产品名称: | Antalarmin hydrochloride |
| CAS No.: | 220953-69-5 |
| Chemical Name: | N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride |
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| 分子量: | 415 |
| 分子式: | C24H34N4 • HCl |
| SMILES: | CC1=C(C)C2=C(N(CC)CCCC)N=C(C)N=C2N1C3=C(C)C=C(C)C=C3C.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Antalarmin (hydrochloride) 是一种非肽类促肾上腺皮质激素释放激素受体1 (CRHR1) 拮抗剂，其Ki为 1 nM。Antalarmin hydrochloride 抑制动物模型中 CRH 诱导的 ACTH 分泌，并阻断 CRH 和新奇感诱导的焦虑样行为。Antalarmin hydrochloride 在关节炎模型中产生抗炎作用，并抑制与肠易激综合征相关的应激性胃溃疡。 |
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Webster, E.L., Lewis, D.B., Torpy, D.J., et al.In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammationEndocrinology137(12),5747-5750(1996)
Deak, T., Nguyen, K.T., Ehrlich, A.L., et al.The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stressEndocrinology140(1),79-86(1999)
Fahmy, H., Spyridaki, K., Kuppast, B., et al.The "homeostasis hormone" and its CRF1 receptor. From structure to functionHormones (Athens)11(3),254-271(2012)
