Noladin ether
Cat. No.：YN322401
| 产品名称: | Noladin ether |
| CAS No.: | 222723-55-9 |
| Chemical Name: | 5Z,8Z,11Z,14Z-eicosatetraen-2-glyceryl ether |
| Synonyms: | |
| 分子量: | 364.6 |
| 分子式: | C23H40O3 |
| SMILES: | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CO)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Noladin ether 是一种有效的，选择性的大麻素CB1受体激动剂，Ki值为 21.2 nM。Noladin ether 可导致体温过低、肠道不动和轻度的缓解疼痛作用。 |
| IC50和靶点: | [{name:"CB1:21.2 nM (Ki)"},{name: "CB2:>3 mM (Ki)"}] |
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Hanus, L., Abu-Lafi, S., Fride, E., et al.2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptorProc. Natl. Acad. Sci. USA98(7),3662-3665(2001)
Ryberg, E., Larsson, N., Sjögren, S., et al.The orphan receptor GPR55 is a novel cannabinoid receptorBr. J. Pharmacol.152(7),1092-1101(2007)
Laine, K., Jarvinen, K., Mechoulam, R., et al.Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoidInvest. Ophthalmol. Vis. Sci.43(10),3216-3222(2002)
Sugiura, T., Kodaka, T., Nakane, S., et al.Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compoundsJ. Biol. Chem.274(5),2794-2801(1999)
Njie, Y.F., Kumar, A., Qiao, Z., et al.Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facilityInvest. Ophthalmol. Vis. Sci.47(5),1999-2005(2006)
Deshmukh, R.R., and Sharma, P.L.Stimulation of accumbens shell cannabinoid CB1 receptors by noladin ether, a putative endocannabinoid, modulates food intake and dietary selection in ratsPharmacol. Res.66(3),276-282(2012)
