Sitravatinib malate
Cat. No.：YN380376
| 产品名称: | Sitravatinib malate |
| CAS No.: | 2244864-88-6 |
| Chemical Name: | |
| Synonyms: | MGCD516 malate; MG-516 malate |
| 分子量: | 763.76 |
| 分子式: | C37H35F2N5O9S |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sitravatinib malate (MGCD516 malate) 是一种有口服活性的受体酪氨酸激酶 (RTK) 抑制剂。抑制Axl，MER，VEGFR3，VEGFR2，VEGFR1，KIT，FLT3，DDR2，DDR1，TRKA，和TRKB，IC50分别为 1.5 nM，2 nM，2 nM，5 nM，6 nM，6 nM，8 nM，0.5 nM，29 nM，5 nM，和 9 nM。Sitravatinib malate 单独使用即具有有效的抗肿瘤功效，且通过促进抗肿瘤免疫微环境增强了PD-1阻断的活 |
| IC50和靶点: | [{name:"VEGFR1:6 nM (IC50)"},{name: "VEGFR2:5 nM (IC50)"},{name: "VEGFR3:2 nM (IC50)"},{name: "TrkA:5 nM (IC50)"},{name: "TrkB:9 nM (IC50)"},{name: "DDR1:29 nM (IC50)"},{name: "DDR2:0.5 nM (IC50)"},{name: "Axl:1.5 nM (IC50)"},{name: "MER:2 nM (IC50)"},{name: "KIT:6 nM (IC50)"},{name: "FLT3:8 nM (IC50)"}] |
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