NPS 2390
Cat. No.：YN322409
CAS No. ：226878-01-9
| 产品名称: | NPS 2390 |
| CAS No.: | 226878-01-9 |
| Chemical Name: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Synonyms: | NPS2390; NPS 2390; NPS-2390. |
| 分子量: | 307.4 |
| 分子式: | C19H21N3O |
| SMILES: | O=C(N[C@]1(C[C@H](C2)C3)C[C@H]3CC2C1)C4=NC5=C(N=C4)C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NPS 2390 是mGluR1和mGluR5的非竞争性拮抗剂。NPS 2390 也是一种有效的钙敏感受体抑制剂。 |
| IC50和靶点: | |
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Ferraguti, F., Crepaldi, L., and Nicoletti, F.Metabotropic glutamate 1 receptor: Current concepts and perspectivesPharmacol. Rev.60(4),536-581(2008)
Mabire, D., Coupa, S., Adelinet, C., et al.Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonistsJ. Med. Chem.48(6),2134-2153(2005)
VanWagenen, B.C., Smith, D.L., Artman, L.D., et al.Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonistSoc. Neurosci.,1-2(2000)
Lavreysen, H., Janssen, C., Bischoff, F., et al.[3H]R214127: A novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonistsMol. Pharmacol.63(5),1082-1093(2003)
