CART(62-76)(human,rat)
Cat. No.：YN322410
| 产品名称: | CART(62-76)(human,rat) |
| CAS No.: | 227449-73-2 |
| Chemical Name: | 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide, dihydrochloride |
| Synonyms: | |
| 分子量: | 413.2 |
| 分子式: | C14H15F3N6O • 2HCl |
| SMILES: | NCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Syk InhibitorII dihydrochloride 是一种有效的，高选择性和 ATP 竞争性Syk抑制剂，IC50为 41 nM。Syk InhibitorII dihydrochloride 抑制 RBL 细胞释放5-HT，IC50为 460 nM。Syk InhibitorII dihydrochloride 对其他激酶的作用较小，并具有抗过敏作用。 |
| IC50和靶点: | [{name:"5-HT Receptor:460 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hisamichi, J., Naito, R., Toyoshima, A., et al.Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivativesBioorg. Med. Chem.13(16),4936-4951(2005)
