EP4 receptor antagonist 1
Cat. No.：YN322411
| 产品名称: | EP4 receptor antagonist 1 |
| CAS No.: | 2287259-07-6 |
| Chemical Name: | 4-[(1S)-1-[[[4-(1E)-1-propen-1-yl-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-1,2,3-triazol-5-yl]carbonyl]amino]ethyl]-benzoic acid |
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| 分子量: | 458.4332096 |
| 分子式: | C23H21F3N4O3 |
| SMILES: | C[C@@H](C1=CC=C(C=C1)C(O)=O)NC(C2=C(/C=C/C)N=NN2CC3=CC=C(C(F)(F)F)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EP4 receptor antagonist 1 是一种高效的，竞争性的，选择性前列腺素类 EP4 受体拮抗剂。可用于癌症免疫研究。EP4 receptor antagonist 1 抑制人和小鼠 EP4 受体，IC50分别为 6.1 nM 和 16.2 nM。对人 EP1，EP2 和 EP3 受体的 IC50>10 μM。 |
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Yang, J.-J., Yu, W.-W., Hu, L.-L., et al.Discovery and characterization of 1 H-1,2,3-triazole derivatives as novel prostanoid EP4 receptor antagonists for cancer immunotherapyJ. Med. Chem.63(2),569-590(2020)
