BMS-470539 dihydrochloride
Cat. No.：YN322415
CAS No. ：2341796-82-3
| 产品名称: | BMS-470539 dihydrochloride |
| CAS No.: | 2341796-82-3 |
| Chemical Name: | 1-[1-(3-methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone, dihydrochloride |
| Synonyms: | |
| 分子量: | 632.6 |
| 分子式: | C32H41N5O4 • 2HCl |
| SMILES: | O=C([C@@H](CC1=CC=C(OC)C=C1)NC([C@@H](N)CC2=CN=CN2C)=O)N3CCC(C4=CC=CC=C4)(C(CCC)=O)CC3.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-470539 dihydrochloride 是一种高效的选择性黑皮质素 1 受体 (MC-1 R) 激动剂，IC50为 120 nM，EC50为 28 nM。BMS-470539 dihydrochloride 不激活 MC-3R，并且对 MC-4R 和 MC-5R 的激活活性非常弱。BMS-470539 dihydrochloride 具有强效的抗炎特性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kang, L., McIntyre, K.W., Gillooly, K.M., et al.A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in miceJ. Leukoc. Biol.80(4),897-904(2006)
Rossi, S., Maisto, R., Gesualdo, C., et al.Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathyMediators Inflamm.2016(7368389),(2016)
Cai, W., Srivastava, P., Feng, D., et al.Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's diseaseMol. Neurodegener.17(1),16(2022)
