CID 2745687
Cat. No.：YN322439
CAS No. ：264233-05-8
| 产品名称: | CID 2745687 |
| CAS No.: | 264233-05-8 |
| Chemical Name: | 1-(2,4-difluorophenyl)-5-[[2-[[(1,1-dimethylethyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid, methyl ester |
| Synonyms: | |
| 分子量: | 395.4 |
| 分子式: | C17H19F2N5O2S |
| SMILES: | O=C(OC)C1=C(/C=N/NC(NC(C)(C)C)=S)N(C2=CC=C(F)C=C2F)N=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CID 2745687 是一种特异性、可逆和竞争性的GPR35拮抗剂，Ki为 12.8 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Wang, J., Simonavicius, N., Wu, X., et al.Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35J. Biol. Chem.281(31),22021-22028(2006)
MacKenzie, A.E., Lappin, J.E., Taylor, D.L., et al.GPR35 as a novel therapeutic targetFront. Endocrinol. (Lausanne)2,68(2011)
O'Dowd, B.F., Nguyen, T., Marchese, A., et al.Discovery of three novel G-protein-coupled receptor genesGenomics47,310-313(1998)
Okumura, S.i., Baba, H., Kumada, T., et al.Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cellsCancer Sci.95(2),131-135(2004)
Zhao, P., Sharir, H., Kapur, A., et al.Targeting of the orphan receptor GPR35 by pamoic acid: A potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activityMol. Pharmacol.78(4),560-568(2010)
Heynen-Genel, S., Dahl, R., Shi, S., et al.Selective GPR35 antagonists: Antagonists for the orphan receptor GPR35Probe 3,1-18(2011)
