(ring-d
Cat. No.：YN322442
CAS No. ：26615-21-4
| 产品名称: | (ring-d |
| CAS No.: | 26615-21-4 |
| Chemical Name: | 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-ethanamine |
| Synonyms: | |
| 分子量: | 331.9 |
| 分子式: | C18H18ClNOS |
| SMILES: | CN(C)CCOC1=CC(C=CC=C2)=C2SC3=C1C=C(Cl)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zotepine，一种抗精神病剂，是有效的5-HT2A，5-HT2C，组胺H1，α1-adrenergic和多巴胺D2受体拮抗剂，Kd值分别为 2.6 nM、3.2 nM、3.3 nM、7.3 nM 和 8 nM。Zotepine 在体内表现出抗抑郁和抗焦虑作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Vanhauwe, J.F., Ercken, M., van de Wiel, D., et al.Effects of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signaling in Chinese hamster ovary cellsPsychopharmacology (Berl.)150(4),383-390(2000)
Czyrak, A., Jaros, T., Moryl, E., et al.Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptorsPharmacopsychiatry26(2),53-58(1993)
Lai, H., Carino, M.A., Sperry, R., et al.Effects of microinjection of 2-chloro-11 (2-dimethylaminoethoxy)-dibenzo[b,f]-thiepine (zotepine), thioridazine and haloperidol into the striatum and nucleus accumbens on stereotypic behaviour and motor activityJ. Pharm. Pharmacol.33(4),252-254(1981)
