8-Isoprostaglandin E2
Cat. No.：YN322443
| 产品名称: | 8-Isoprostaglandin E2 |
| CAS No.: | 27415-25-4 |
| Chemical Name: | (8β)-11α,15S-dihydroxy-9-oxo-prosta-5Z,13E-dien-1-oic acid |
| Synonyms: | iPE2-III |
| 分子量: | 352.5 |
| 分子式: | C20H32O5 |
| SMILES: | O[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H](C/C=C\CCCC(O)=O)C(C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Isoprostaglandin E2 (iPE2-III) 是异前列腺素类的一员。8-Isoprostaglandin E2 在体内作用于血栓素A2(TP) 受体，诱导血管收缩和血小板聚集。8-Isoprostaglandin E2 通过 cAMP 途径增强受体激活的 NFκB 配体(RANKL) 依赖的骨髓造血前体破骨潜能。 |
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Morrow, J.D., Minton, T.A., Mukundan, C.R., et al.Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanesJ. Biol. Chem.269(6),4317-4326(1994)
Hoffman, S.W., Moore, S., and Ellis, E.F.Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arteriolesStroke28(4),844-884(1997)
Longmire, A.W., Roberts, L.J., and Morrow, J.D.Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptorProstaglandins48(4),247-256(1994)
