VUF-5574
Cat. No.：YN322447
| 产品名称: | VUF-5574 |
| CAS No.: | 280570-45-8 |
| Chemical Name: | N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-urea |
| Synonyms: | |
| 分子量: | 371.39218 |
| 分子式: | C21H17N5O2 |
| SMILES: | O=C(NC1=C(OC)C=CC=C1)NC2=NC(C3=CN=CC=C3)=NC4=C2C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VUF-5574 是一种选择性的腺苷A3受体拮抗剂，对重组人受体的Ki为 4.03 nM。 |
| IC50和靶点: | [{name:"Recombinant Human Adenosine A3 receptor (A3R):4.03 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
van Muijwijk-Koezen, J.E., Timmerman, H., van der Goot, H., et al.Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptorJ. Med. Chem.43(11),2227-2238(2000)
Shen, J., Halenda, S.P., Sturek, M., et al.Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptorCirc. Res.97(6),574-582(2005)
Pugliese, A.M., Coppi, E., Spalluto, G., et al.A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitroBr. J. Pharmacol.147(5),524-532(2006)
El-Mas, M.M., El-Gowilly, S.M., Fouda, M.A., et al.Role of adenosine A2A receptor signaling in the nicotine-evoked attenuation of reflex cardiac sympathetic controlToxicol. Appl. Pharmacol.254(3),229-237(2011)
