JTE-907
Cat. No.：YN322450
| 产品名称: | JTE-907 |
| CAS No.: | 282089-49-0 |
| Chemical Name: | N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide |
| Synonyms: | 3-Quinolinecarboxamide,N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-;3-Quinolinecarboxamide,N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy...;JTE 907;N-(1,3-benzodioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pen |
| 分子量: | 438.5 |
| 分子式: | C24H26N2O6 |
| SMILES: | O=C1NC2=C(OCCCCC)C(OC)=CC=C2C=C1C(NCC3=CC=C(OCO4)C4=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JTE-907 是高度选择性，有口服活性的CB2受体反向激动剂，在体内表现出抗炎活性。 |
| IC50和靶点: | |
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Iwamura, H., Suzuki, H., Ueda, Y., et al.In vitro and in vivo pharmacological characterization of JTE-907, a novel selection ligand for cannabinoid CB2 receptorJ. Pharmacol. Exp. Ther.296(2),420-425(2001)
Gentili, M., Ronchetti, S., Ricci, E., et al.Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel diseasePharmacol. Res.141,21-31(2019)
Maekawa, T., Nojima, H., Kuraishi, Y., et al.The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitisEuro. J. Pharmacol.542(1-3),179-183(2006)
Gomes-de-Souza, L., Bianchi, P.C., Costa-Ferreira, W., et al.CB1 and CB2 receptors in the bed nucleus of the stria terminalis differently modulate anxiety-like behaviors in ratsProg. Neuropsychopharmacol. Biol. Psychiatry110,110284(2021)
