VU0155041 sodium
Cat. No.：YN322457
| 产品名称: | VU0155041 sodium |
| CAS No.: | 302841-89-0 |
| Chemical Name: | N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester |
| Synonyms: | |
| 分子量: | 325.4 |
| 分子式: | C19H19NO4 |
| SMILES: | O=C(NC(OCCCC)=O)C1C2=CC=CC=C2OC3=C1C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro 67-4853 是mGluR1的正向变构调节剂 (PAM)，对于 rmGlu1a 受体的pEC50为7.16。Ro67-4853在包括 hmGlu1、rmGlu1 和 rmGlu5 在内的所有I 型 mGlu 受体上显示活性。Ro 67-4853 通过与受体的跨膜结构域 (TMD) 相互作用增强L-谷氨酸的效力。Ro 67-4853 增强对重复振动刺激的感觉突触反应。 |
| IC50和靶点: | [{name:"Rat mGluR1a:7.16 (pEC50)"}] |
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Hemstapat, K., de Paulis, T., Chen, Y., et al.A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulatorsMol. Pharmacol.70(2),616-626(2006)
Sheffler, D.J., and Conn, P.J.Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsNeuropharmacology55(4),419-427(2008)
Salt, T.E., Jones, H.E., Andolina, I.M., et al.Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulatorNeuropharmacology62(4),1695-1699(2012)
