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Cyclizine hydrochloride

Cat. No.:YN322458

  • CAS No. :303-25-3

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Cyclizine hydrochloride
      CAS No.: 303-25-3
      Chemical Name: 1-(diphenylmethyl)-4-methyl-piperazine, monohydrochloride
      Synonyms:盐酸苯甲嗪
      分子量:302.8414
      分子式:C18H22N2 • HCl
      SMILES:CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Cyclizine hydrochloride,一种哌嗪衍生物,是一种有效的选择性组胺H1受体拮抗剂。Cyclizine hydrochloride 可用于恶心、呕吐和头晕的研究。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Hamlin, K.E., Weston, A.W., Fischer, F.E., et al.Histamine antagonists. II.1 Unsymmetrical 1,4-disubstituted piperazinesJ. Am. Chem. Soc.71(8),2731-2734(2019)

      Králová, J., Račková, L., Pekarová, M., et al.The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicityInt. Immunopharmacol.9(7-8),990-995(2009)

      Hill, S.J.Distribution, properties, and functional characteristics of three classes of histamine receptorPharmacol. Rev.42(1),45-83(1990)

      Church, M.K., and Gradidge, C.F.Inhibition of histamine release from human lung in vitro by antihistamines and related drugsBr. J. Pharmacol.69(4),663-667(2019)

      Khanwelkar, C.C., Gokhale, D.V., Santakke, A.V., et al.Effects of H1–receptor antagonists in antidepressant tests in ratsAl Ameen J. Med. Sci.1(2),84-92(2008)

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