GPR109 receptor agonist-1
Cat. No.：YN322460
CAS No. ：306935-41-1
| 产品名称: | GPR109 receptor agonist-1 |
| CAS No.: | 306935-41-1 |
| Chemical Name: | 1-(1-methylethyl)-1H-benzotriazole-5-carboxylic acid |
| Synonyms: | IBC 293; IBC293; IBC-293. |
| 分子量: | 205.2 |
| 分子式: | C10H11N3O2 |
| SMILES: | OC(C1=CC=C(N(C(C)C)N=N2)C2=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GPR109 receptor agonist-1 (Compound 3a) 是一种高选择性的人孤儿 G 蛋白偶联受体GPR109b激动剂，pEC50为 6.4。GPR109 receptor agonist-1 可用于心脏代谢疾病的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ahmed, K., Tunaru, S., and Offermanns, S.GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptorsTrends Pharmacol. Sci.30(11),557-562(2009)
Offermanns, S., Colletti, S.L., Lovenberg, T.W., et al.International union of basic and clinical pharmacology. LXXXII: Nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)Pharmacol. Rev.63(2),269-290(2011)
Semple, G., Skinner, P.J., Cherrier, M.C., et al.1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109bJ. Med. Chem.49(4),1227-1230(2006)
Zhou, Q., Li, G., Deng, X.Y., et al.Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathwaysBr. J. Pharmacol.166(6),1756-1773(2012)
