BMS-986122
Cat. No.：YN322463
CAS No. ：313669-88-4
| 产品名称: | BMS-986122 |
| CAS No.: | 313669-88-4 |
| Chemical Name: | 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine |
| Synonyms: | |
| 分子量: | 448.8 |
| 分子式: | C16H15BrClNO3S2 |
| SMILES: | COC1=CC=C(C2N(S(C3=CC=C(Cl)C=C3)(=O)=O)CCS2)C=C1Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986122 是一种选择性的、有效的μ-阿片受体(µ-OR)正变构调节剂。BMS-986122 显示正构激动剂介导的 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的增强作用。BMS-986122 增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Burford, N.T., Clark, M.J., Wehrman, T.S., et al.Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptorProc. Natl. Acad. Sci. USA110(26),10830-10835(2013)
