MLS1547
Cat. No.：YN322465
CAS No. ：315698-36-3
| 产品名称: | MLS1547 |
| CAS No.: | 315698-36-3 |
| Chemical Name: | 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol |
| Synonyms: | 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol |
| 分子量: | 354.83322 |
| 分子式: | C19H19ClN4O |
| SMILES: | OC1=C(C=C(Cl)C2=C1N=CC=C2)CN(CC3)CCN3C4=CC=CC=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MLS1547 是一种高效的 G 蛋白偏向多巴胺 D2 受体(D2R)激动剂。MLS1547 刺激 D2R G 蛋白介导的信号传导，EC50值为 0.37 μM。MLS1547 可作为多巴胺 (DA) 刺激的 β-arrestin 募集到 D2R 的拮抗剂 (IC50=9.9 μM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Free, R.B., Chun, L.S., Moritz, A.E., et al.Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptorMol. Pharmacol.86(1),96-105(2014)
Moir, D.T., Di, M., Wong, E., et al.Development and application of a cellular, gain-of-signal, bioluminescent reporter screen for inhibitors of type II secretion in Pseudomonas aeruginosa and Burkholderia pseudomalleiJ. Biomol. Screen.16(7),694-705(2011)
