SCH442416
Cat. No.：YN322466
CAS No. ：316173-57-6
| 产品名称: | SCH442416 |
| CAS No.: | 316173-57-6 |
| Chemical Name: | 2-(2-furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
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| 分子量: | 389.4 |
| 分子式: | C20H19N7O2 |
| SMILES: | NC1=NC2=C(C=NN2CCCC3=CC=C(OC)C=C3)C4=NC(C5=CC=CO5)=NN14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SCH442416 是一种有效，选择性和可透过血脑屏障的腺苷A2A受体 (A2AR) 拮抗剂，对人和大鼠 A2AR 的Ki值分别为 0.048 和 0.5 nM。SCH442416 在 A1R，A2BR 和 A3R (Ki=1111，10000，10000 nM) 上显示出超过 23000 倍的选择性。SCH442416 可用于在大鼠和灵长类动物大脑中对腺苷 A2A受体成像。 |
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Todde, S., Moresco, R.M., Simonelli, P., et al.Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomographyJ. Med. Chem.43(23),4359-4362(2000)
Maimon, N., Titus, P.A., and Sarelius, I.H.Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arteriolesJ. Physiol.52(12),2575-2590(2014)
