SIB-1757
Cat. No.：YN322468
| 产品名称: | SIB-1757 |
| CAS No.: | 31993-01-8 |
| Chemical Name: | 6-methyl-2-(2-phenyldiazenyl)-3-pyridinol |
| Synonyms: | SIB-1757; SIB 1757; SIB1757. |
| 分子量: | 213.23536 |
| 分子式: | C12H11N3O |
| SMILES: | OC1=C(/N=N/C2=CC=CC=C2)N=C(C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SIB-1757 是一种高选择性、非竞争性的mGlu5 受体拮抗剂，其IC50值为 0.4 μM。 |
| IC50和靶点: | [{name:"human mGluR5:0.4 μM (IC50)"}] |
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Varney, M.A., Cosford, N.D., Jachec, C., et al.SIB-1757 and SIB-1893: Selective, noncompetitive antagonists of metabotropic glutamate receptor type 5J. Pharmacol. Exp. Ther.290(1),170-181(1999)
Dogrul, A., Ossipov, M.H., Lai, J., et al.Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in ratsNeurosci. Lett.292(2),115-118(2000)
