AS1269574
Cat. No.：YN322474
CAS No. ：330981-72-1
| 产品名称: | AS1269574 |
| CAS No.: | 330981-72-1 |
| Chemical Name: | 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-ethanol |
| Synonyms: | AS-1269574|AS1269574 |
| 分子量: | 308.2 |
| 分子式: | C13H14BrN3O |
| SMILES: | BrC(C=C1)=CC=C1C2=NC(NCCO)=CC(C)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AS1269574 是一种有效的，具有口服活性的GPR119激动剂，在表达人GPR119的 HEK293 细胞中EC50为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。 |
| IC50和靶点: | |
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Overton, H.A., Babbs, A.J., Doel, S.M., et al.Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agentsCell Metab.3(3),167-175(2006)
Soga, T., Ohishi, T., Matsui, T., et al.Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptorBiochem. Biophys. Res. Commun.326(4),744-751(2005)
Yoshida, S., Ohishi, T., Matsui, T., et al.Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretionBiochem. Biophys. Res. Commun.400(3),437-441(2010)
