2-Oleoylglycerol
Cat. No.：YN322480
CAS No. ：3443-84-3
| 产品名称: | 2-Oleoylglycerol |
| CAS No.: | 3443-84-3 |
| Chemical Name: | 2-hydroxy-1-(hydroxymethyl)ethyl ester-9Z-octadecenoic acid |
| Synonyms: | 2-十八烯酸单甘油酯；2-甘油单油酸酯 |
| 分子量: | 356.5 |
| 分子式: | C21H40O4 |
| SMILES: | CCCCCCCC/C=C\CCCCCCCC(OC(CO)CO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 2-Oleoylglycerol 是饮食中天然存在的脂质。2-Oleoylglycerol 是一种GPR119激动剂，在瞬时转染的 COS-7 细胞中激活 hGPR119 的EC50值为 2.5 μM。2-Oleoylglycerol 在体内刺激胰高血糖素样肽 1 (GLP-1) 分泌。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brengdahl, J., and Fowler, C.J.A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screeningAnal. Biochem.359(1),40-44(2006)
Ghafouri, N., Tiger, G., Razdan, R.K., et al.Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerolBr. J. Pharmacol.143(6),774-784(2004)
Woodhams, S.G., Wong, A., Barrett, D.A., et al.Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the ratBr. J. Pharmacol.167(8),1609-1619(2012)
Hansen, K.B., Rosenkilde, M.M., Knop, F.K., et al.2-Oleoyl glycerol is a GRP119 agonist and signals GLP-1 release in humansJ. Clin. Endocrinol. Metab.96(9),E1409-E1417(2011)
