TCS 2510
Cat. No.:YN322483
CAS No. :346673-06-1
产品名称: | TCS 2510 |
CAS No.: | 346673-06-1 |
Chemical Name: | 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
Synonyms: | CAY10598 |
分子量: | 383.5 |
分子式: | C21H29N5O2 |
SMILES: | O=C1N(CCCCCCC2=NN=NN2)[C@](/C=C/[C@@H](O)CC3=CC=CC=C3)([H])CC1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | TCS 2510 是一种选择性EP4激动剂。TCS 2510 可用于代谢疾病的研究。 |
IC50和靶点: | |
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Li, M., Thompson, D.D., and Paralkar, V.M.Prostaglandin E2 receptors in bone formationInt. Orthop.31(6),767-772(2007)
Hawcroft, G., Ko, C.W.S., and Hull, M.A.Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cellsOncogene26(21),3006-3019(2007)
Babaev, V.R., Chew, J.D., Ding, L., et al.Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosisCell Metab.8(6),492-501(2008)
Billot, X., Chateauneuf, A., Chauret, N., et al.Discovery of a potent and selective agonist of the prostaglandin EP4 receptorBioorg. Med. Chem. Lett.13(6),1129-1132(2003)
Yamane, H., Sugimoto, Y., Tanaka, S., et al.Prostaglandin E2 receptors, EP2 and EP4, differentially modulate TNF-α and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophilsBiochem. Biophys. Res. Commun.278,224-228(2000)
Marui, A., Hirose, K., Maruyama, T., et al.Prostaglandin E2 EP4 receptor-selective agonist facilitates sternal healing after harvesting bilateral internal thoracic arteries in diabetic ratsJ. Thorac. Cardiovasc. Surg.131(3),587-593(2006)
Xiao, C.Y., Yuhki, K.i., Hara, A., et al.Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4Circulation109,2462-2468(2004)
Ahmad, A.S., Ahmad, M., de Brum-Fernandes, A.J., et al.Prostaglandin EP4 receptor agonist protects against acute neurotoxicityBrain Res.1066,71-77(2005)
Li, J.H., Chou, C.L., Li, B., et al.A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidusJ. Clin. Invest.119(10),3115-3126(2009)