5'-Guanidinonaltrindole hydrochloride
Cat. No.：YN322484
| 产品名称: | 5'-Guanidinonaltrindole hydrochloride |
| CAS No.: | 351183-88-5 |
| Chemical Name: | [(4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-1,8a-dihydroxy-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazol-11-yl]-guanidine, dihydrochloride |
| Synonyms: | 5'-GNTI hydrochloride |
| 分子量: | 544.47234 |
| 分子式: | C27H29N5O3 • 2HCl |
| SMILES: | O[C@]12[C@@]34C5=C(C[C@H]2N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C7=C(C8=CC(NC(N)=N)=CC=C8N7)C1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5'-Guanidinonaltrindole (5'-GNTI) hydrochloride 是一种高选择性的、有效的κ-opioid receptor拮抗剂，对人 κ-opioid 受体的Ki为 0.18 nM。 |
| IC50和靶点: | [{name:"human μ-opioid receptor:36.9 nM (Ki)"},{name: "human μ-opioid receptor:8.49 (pA2)"}] |
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| Solvent & Solubility: |
Jones, R.M., and Portoghese, P.S.5'-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonistEur. J. Pharmacol.396(1),49-52(2000)
Lee, Y.-C., Lin, C.-H., Hung, S.-Y., et al.Manual acupuncture relieves bile acid-induced itch in mice: The role of microglia and TNF-αInt. J. Med. Sci.15(9),953-960(2018)
