VU0410425
Cat. No.：YN322487
| 产品名称: | VU0410425 |
| CAS No.: | 353229-59-1 |
| Chemical Name: | 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)-ethanesulfonamide |
| Synonyms: | LY487379 hydrochloride |
| 分子量: | 488.91 |
| 分子式: | C21H20ClF3N2O4S |
| SMILES: | Cl.COC1=CC=CC=C1OC1C=CC(N(S(CC(F)(F)F)(=O)=O)CC2C=CC=NC=2)=CC=1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY487379 hydrochloride 是一种选择性人mGluR2正变构调节剂 (PAM)。LY487379 hydrochloride 增强谷氨酸刺激[35S]GTPγS 与EC50值分别为 1.7 μM 和 >10 μM 的 mGlu2 和 mGlu3 受体的结合。LY487379 hydrochlorid 可促进大鼠认知灵活性，促进行为抑制。LY487379 hydrochlorid 可用于精神分裂症研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wieronska, J. et al.: Neuropharmacol., 62, 322 (2012)
Pinkerton, A. et al.: Bioorg. Med. Chem. Lett., 14, 5867 (2004)
