β2AR/M3-receptor agonist-1
Cat. No.：YN380387
| 产品名称: | β2AR/M3-receptor agonist-1 |
| CAS No.: | 36067-72-8 |
| Chemical Name: | 6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine, dihydrochloride |
| Synonyms: | B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride |
| 分子量: | 254.2 |
| 分子式: | C9H15N3O • 2HCl |
| SMILES: | CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Azepexole (B-HT 933) dihydrochloride 是一种有效的选择性α 2肾上腺素受体激动剂，对 α2A-、α2B- 和 α2C- 肾上腺素受体亚型的pKi分别为 8.3、7.6 和 7.5。Azepexole dihydrochloride 引起浓度依赖性的蠕动收缩抑制 (IC50= 78.72 nM)。 |
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Ruffolo, R.R., Jr., and Zeid, R.L.Relationship between alpha 2-adrenoceptor occupancy and response for B-HT 933 in canine saphenous veinEur. J. Pharmacol.111(2),267-271(1985)
Vargas, M.L., and Brugger, A.J.Mechanism of action of B-HT 933 (azepexole) in rat vas deferens and guinea-pig ileumEur. J. Pharmacol.119(3),137-141(1985)
Anden, N.-E.Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT920 and B-HT933, respectivelyNaunyn-Schmiedebergs Arch. Pharmacol.321,100-104(1982)
Santa-Maria, I., Hernandez, F., Del Rio, J., et al.Tramiprostate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tauMol. Neurodegener.2,17-29(2007)
Vargas, M.L., Bansinath, M., Turndorf, H., et al.Antinociceptive effects of azepexole (BHT 933) in micePain36(1),117-123(1989)
