Cimetidine sulfoxide
Cat. No.：YN322490
| 产品名称: | Cimetidine sulfoxide |
| CAS No.: | 36376-47-3 |
| Chemical Name: | 4-methyl-1H-imidazole-5-ethanamine, dihydrochloride |
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| 分子量: | 198.1 |
| 分子式: | C6H11N3 • 2HCl |
| SMILES: | NCCC1=C(C)NC=N1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-Methylhistamine (dihydrochloride) 是组胺 4 受体 (H4R) 的有效激动剂。4-Methylhistamine (dihydrochloride) 具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力。 |
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Lim, H.D., van Rijn, R.M., Ling, P., et al.Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: Identification of 4-methylhistamine as the first potent and selective H4 receptor agonistJ. Pharmacol. Exp. Ther.314(3),1310-1321(2005)
Morgan, R.K., McAllister, B., Cross, L., et al.Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine modelJ. Immunol.178(12),8081-8089(2007)
Kim, C.H., Lee, J.M., Yoo, J.K., et al.Inhibitory effect of imiquimod-induced psoriasis-like skin inflammation in mice by histamine H4 receptor agonist 4-methylhistamineScand. J. Immunol.83(6),409-417(2016)
