UCM707
Cat. No.：YN322500
| 产品名称: | UCM707 |
| CAS No.: | 390824-20-1 |
| Chemical Name: | N-(3-furanylmethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide |
| Synonyms: | |
| 分子量: | 383.6 |
| 分子式: | C25H37NO2 |
| SMILES: | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCc1cocc1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UCM707 是一种有效和选择性的内源性大麻素摄取 (endocannabinoid uptake) 抑制剂，可增强 Anandamide 的运动功能减退和镇痛作用。 |
| IC50和靶点: | |
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Devane, W.A., Hanus, L., Breuer, A., et al.Isolation and structure of a brain constituent that binds to the cannabinoid receptorScience258(5090),1946-1949(1992)
Deutsch, D.G., Glaser, S.T., Howell, J.M., et al.The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolaseJ. Biol. Chem.276(10),6967-6973(2001)
López-Rodriguez, M.L., Viso, A., Ortega-Gutiérrez, S., et al.Design, synthesis, and biological evaluation of new endocannabinoid transporter inhibitorsEur. J. Med. Chem.38(4),403-412(2003)
de Lago, E., Fernandez-Ruiz, J., Ortega-Gutiérrez, S., et al.UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamideEur. J. Pharmacol.449(1-2),99-103(2002)
