Enprofylline
Cat. No.：YN322505
| 产品名称: | Enprofylline |
| CAS No.: | 41078-02-8 |
| Chemical Name: | 3,9-dihydro-3-propyl-1H-purine-2,6-dione |
| Synonyms: | 恩丙茶碱；恩普菲林 |
| 分子量: | 194.2 |
| 分子式: | C8H10N4O2 |
| SMILES: | O=C(C(N=CN1)=C1N2CCC)NC2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enprofylline 是一种选择性和竞争性的A2B受体拮抗剂，Ki为 7 μM。Enprofylline 还是一种磷酸二酯酶 (phosphodiesterase) 抑制剂。Enprofylline 可用于哮喘、慢性阻塞性肺疾病的研究 |
| IC50和靶点: | [{name:"A2B receptor:7 μM (Ki)"}] |
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Linden, J., Thai, T., Figler, H., et al.Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cellsMol. Pharmacol.56(4),705-713(1999)
Ogawa, K., Takagi, K., and Satake, T.Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscleBr. J. Pharmacol.97(2),542-546(1989)
Schwabe, U., Ukena, D., and Lohse, M.J.Xanthine derivatives as antagonists at A1 and A2 adenosine receptorsNaunyn Schmiedebergs Arch. Pharmacol.330(3),212-221(1985)
Høier, B., Olsen, K.M., Nyberg, M., et al.Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosineAm. J. Physiol. Heart. Circ. Physiol.299(3),H857-H862(2010)
Koëter, G.H., Kraan, J., Boorsma, M., et al.Effect of theophylline and enprofylline on bronchial hyperresponsivenessThorax44(12),1022-1026(1989)
