Casopitant mesylate
Cat. No.：YN322507
| 产品名称: | Casopitant mesylate |
| CAS No.: | 414910-30-8 |
| Chemical Name: | (2R,4S)-4-(4-Acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperidinecarboxamide Methanesulfonate; GW 679769B; |
| Synonyms: | GW679769B |
| 分子量: | 712.72 |
| 分子式: | C31H39F7N4O5S |
| SMILES: | CN(C(N1[C@@H](C2=C(C)C=C(F)C=C2)C[C@@H](N2CCN(C(=O)C)CC2)CC1)=O)[C@@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C.CS(=O)(=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Casopitant mesylate (GW679769B) 是一种有效的，选择性的，脑通透性和口服活性神经激肽 1 (NK1) 受体拮抗剂。Casopitant mesylate 是第二类止吐药，可拮抗 substance P 的催吐作用。Casopitant mesylate 也是一种CYP3A4的底物和弱至中度抑制剂。Casopitant mesylate 可用于化疗引起的恶心和呕吐 (CINV) 和术后恶心和呕吐 (PONV)。 |
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Hesketh, P., et al.: Eur. J. Cancer., 39, 1074 (2003), Kris, M., et al.: J. Clin. Oncol., 24, 2932 (2006), Minthorn, E., et al.: Drug Metab. Dispos., 36, 1846 (2008),
