VPC 23019
Cat. No.:YN322519
产品名称: | VPC 23019 |
CAS No.: | 449173-19-7 |
Chemical Name: | (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate |
Synonyms: | VPC 23019;(R)-phosphoric acid mono-[2-amino-2-(3-octyl-phenylcarbamoyl)-ethyl] ester;N-(3-Octylphenyl)-O-phosphono-D-serinamide |
分子量: | 372.4 |
分子式: | C17H29N2O5P |
SMILES: | O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | VPC 23019,一种含芳基酰胺的鞘氨醇 1-磷酸(S1P) receptor调节剂,S1P1和S1P3受体的竞争性拮抗剂 (pKis=7.86 和 5.93),S1P4和S1P5的激动剂 (pEC50s=6.58 和 7.07)。 |
IC50和靶点: | |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Takuwa, Y., Takuwa, N., and Sugimoto, N.The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activitiesJ. Biochem.131(6),767-771(2002)
Ishii, I., Fukushima, N., Ye, X., et al.Lysophospholipid receptors: Signaling and biologyAnnu. Rev. Biochem.73,321-354(2004)
Kluk, M.J., and Hla, T.Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptorsBiochim. Biophys. Acta1582(1-3),72-80(2002)
Davis, M.D., Clemens, J.J., Macdonald, T.L., et al.Sphingosine 1-phosphate analogs as receptor antagonistsJ. Biol. Chem.280(11),9833-9841(2005)
Takabe, K., Paugh, S.W., Milstien, S., et al."Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targetsPharmacol. Rev.60(2),181-195(2008)