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VPC 23019

Cat. No.:YN322519

  • CAS No. :449173-19-7

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    • 生物活性
    • 参考文献
    • 产品名称: VPC 23019
      CAS No.: 449173-19-7
      Chemical Name: (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate
      Synonyms:VPC 23019;(R)-phosphoric acid mono-[2-amino-2-(3-octyl-phenylcarbamoyl)-ethyl] ester;N-(3-Octylphenyl)-O-phosphono-D-serinamide
      分子量:372.4
      分子式:C17H29N2O5P
      SMILES:O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: VPC 23019,一种含芳基酰胺的鞘氨醇 1-磷酸(S1P) receptor调节剂,S1P1和S1P3受体的竞争性拮抗剂 (pKis=7.86 和 5.93),S1P4和S1P5的激动剂 (pEC50s=6.58 和 7.07)。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Takuwa, Y., Takuwa, N., and Sugimoto, N.The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activitiesJ. Biochem.131(6),767-771(2002)

      Ishii, I., Fukushima, N., Ye, X., et al.Lysophospholipid receptors: Signaling and biologyAnnu. Rev. Biochem.73,321-354(2004)

      Kluk, M.J., and Hla, T.Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptorsBiochim. Biophys. Acta1582(1-3),72-80(2002)

      Davis, M.D., Clemens, J.J., Macdonald, T.L., et al.Sphingosine 1-phosphate analogs as receptor antagonistsJ. Biol. Chem.280(11),9833-9841(2005)

      Takabe, K., Paugh, S.W., Milstien, S., et al."Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targetsPharmacol. Rev.60(2),181-195(2008)

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