Ibipinabant
Cat. No.：YN322522
| 产品名称: | Ibipinabant |
| CAS No.: | 464213-10-3 |
| Chemical Name: | 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4S-phenyl-1H-pyrazole-1-carboximidamide |
| Synonyms: | SLV319; BMS-646256 |
| 分子量: | 487.4 |
| 分子式: | C23H20Cl2N4O2S |
| SMILES: | C/N=C(\NS(=O)(=O)c1ccc(Cl)cc1)/N1N=C(c2ccc(Cl)cc2)C(C1)c1ccccc1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ibipinabant (SLV319) 是一种有效，选择性和具有口服活性的大麻素CB1受体 (cannabinoidCB1receptor) 的拮抗剂，Ki值为 7.8 nM。Ibipinabant 对CB1的选择性比对CB2(Ki=7943 nM) 的选择性高 1000 倍以上。Ibipinabant 可用于肥胖和糖尿病的研究。 |
| IC50和靶点: | [{name:"CB1:7.8 nM (Ki)"},{name: "CB2:7943 nM (Ki)"}] |
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Lange, J.H.M., Coolen, H.K.A.C., van Stuivenberg, H.H., et al.Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonistsJ. Med. Chem.47(3),627-643(2004)
Lange, J.H.M., van Stuivenberg, H.H., Veerman, W., et al.Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicityBioorg. Med. Chem. Lett.15,4794-4798(2005)
