Dolasetron Mesylate
Cat. No.：YN322523
| 产品名称: | Dolasetron Mesylate |
| CAS No.: | 467459-31-0 |
| Chemical Name: | 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-indole-3-ethanamine |
| Synonyms: | Lu AE58054 |
| 分子量: | 398.369756 |
| 分子式: | C20H19F5N2O |
| SMILES: | FC(F)C(F)(F)COC1=CC(CNCCC2=CNC3=C2C=CC(F)=C3)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Idalopirdine (Lu AE58054 ) 是有效，选择性的5-HT6受体拮抗剂，Ki为 0.83 nM。Idalopirdine 可用于阿尔茨海默病和精神分裂症等相关疾病的研究。 |
| IC50和靶点: | [{name:"5-HT6 Receptor:0.83 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Arnt, J., Bang-Andersen, B., Grayson, B., et al.Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in ratsInt. J. Neuropsychopharmacol.13(8),1021-1033(2010)
Cherian, A.K., Kucinski, A., Wu, R., et al.Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's diseasePsychopharmacology (Berl)236(6),1701-1715(2019)
