CP-809101
Cat. No.：YN322527
| 产品名称: | CP-809101 |
| CAS No.: | 479683-64-2 |
| Chemical Name: | 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-pyrazine |
| Synonyms: | |
| 分子量: | 304.77454 |
| 分子式: | C15H17ClN4O |
| SMILES: | ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-809101 是一种强效的，高选择性的5-HT2C受体激动剂，其对人5HT2C,5HT2B和5HT2A受体的pEC50值分别为 9.96, 7.19 和 6.81 M。CP-809101 能抑制大鼠的条件回避反应，以及 phencyclidine hydrochloride 和 d-amphetamine 诱导的多动症，还能减少大鼠对食物和尼古丁的依赖。CP-809101 可用于抗精神病以及尼古丁依赖的研究。 |
| IC50和靶点: | [{name:"5-HT2C Receptor:9.96 (pEC50)"},{name: "5-HT2B Receptor:7.19 (pEC50)"},{name: "5-HT2A Receptor:6.81 (pEC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Siuciak, J.A., Chapin, D.S., McCarthy, S.A., et al.CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activityNeuropharmacology52(2),279-290(2007)
Pockros-Burgess, L.A., Pentkowski, N.S., Der-Ghazarian, T., et al.Effects of the 5-HT2C receptor agonist CP809101 in the amygdala on reinstatement of cocaine-seeking behavior and anxiety-like behaviorInt. J. Neuropsychopharmacol.17(11),1751-1762(2014)
Higgins, G.A., Silenieks, L.B., Altherr, E.B., et al.Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonistsPsychopharmacology (Berl)233(14),2841-2856(2016)
