SNAP 94847
Cat. No.：YN322528
| 产品名称: | SNAP 94847 |
| CAS No.: | 487051-12-7 |
| Chemical Name: | N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide |
| Synonyms: | SNAP94847 hydrochloride SNA P94847 SNAP 94847 |
| 分子量: | 478.5734664 |
| 分子式: | C29H32F2N2O2 |
| SMILES: | O=C(C(C)C)NC1=CC=C(C)C(C2CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C(F)=C4)F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SNAP 94847 是一种新型的，高亲和力的选择性黑色素浓缩激素受体 1 (MCHR1) 拮抗剂，其 (Ki= 2.2 nM,Kd=530 pM)，它对MCHα1A和MCHD2受体分别显示出 >80 倍和 >500 倍的选择性。 SNAP 94847 以高亲和力与小鼠和大鼠MCHR1结合，与其他 GPCR，离子通道，酶和转运蛋白的交叉反应性很小。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chen, C.-A., Jiang, Y., Lu, K., et al.Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hitsJ. Med. Chem.50(16),3883-3890(2007)
David, D.J., Klemenhagen, K.C., Holick, K.A., et al.Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesisJ. Pharmacol. Exp. Ther.321(1),237-248(2007)
Verty, A.N.A., Lockie, S.H., Stefanidis, A., et al.Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese miceInt. J. Obes. (Lond)37(2),279-287(2013)
