Physostigmine salicylate
Cat. No.：YN380395
CAS No. ：57-64-7
| 产品名称: | Physostigmine salicylate |
| CAS No.: | 57-64-7 |
| Chemical Name: | 2-hydroxybenzoic acid with (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate |
| Synonyms: | 水杨酸毒扁豆碱; Eserine salicylate |
| 分子量: | 413.467 |
| 分子式: | C15H21N3O2 • C7H6O3 |
| SMILES: | CNC(OC1=CC([C@@](CCN2C)(C)[C@@]2([H])N3C)=C3C=C1)=O.OC(C4=C(O)C=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Physostigmine salicylate (Eserine salicylate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine salicylate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine salicylate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine salicylate 也是抗胆碱能中毒的解毒剂。 |
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Proudfoot, A.The early toxicology of physostigmine: a tale of beans, great men and egosToxicol. Rev.25(2),99-138(2006)
Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8),609-613(2000)
Dieterich, H.A., Kaffel, H., Kilbinger, H., et al.The effects of physostigmine on cholinesterase activity, storage and release of acetylcholine in the isolated chicken heartJ. Pharmacol. Exp. Ther.199(1),236-246(1976)
Szeberényi, J., Varga, A., Pongrácz, M.F., et al.Centrally mediated contraction of the lower eyelid elicited by anticholinesterases in anaesthetized ratsJ. Pharm. Pharmacol.24(1),85-86(1972)
