O-Desmethyl Galanthamine
Cat. No.：YN380397
CAS No. ：60755-80-8
| 产品名称: | O-Desmethyl Galanthamine |
| CAS No.: | 60755-80-8 |
| Chemical Name: | (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol |
| Synonyms: | Sanguinine |
| 分子量: | 273.327 |
| 分子式: | C16H19NO3 |
| SMILES: | OC1=C2C3=C(C=C1)CN(C)CC[C@@]34[C@@](C[C@H](C=C4)O)([H])O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | O-Desmethyl Galanthamine (Sanguinine) 是一种加兰他敏型生物碱。O-Desmethyl Galanthamine 是一种乙酰胆碱酯酶 (AChE) 抑制剂，其IC50值为 1.83 μM。 |
| IC50和靶点: | |
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Maláková, J., Nobilis, M., Svoboda, Z., et al.High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samplesJ. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.853(1-2),265-274(2007)
Bachus, R., Bickel, U., Thomsen, T., et al.The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6Pharmacogenetics9(6),661-668(1999)
Zhu, Y.-Y., Li, X., Yu, H.-Y., et al.Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activitiesArch. Pharm. Res.38(5),604-613(2015)
