MJ15
Cat. No.：YN322572
| 产品名称: | MJ15 |
| CAS No.: | 611207-11-5 |
| Chemical Name: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole |
| Synonyms: | |
| 分子量: | 408.8 |
| 分子式: | C20H20Cl3N3 |
| SMILES: | CCCCCCC1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Cl)C=C3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LH-21 是一种有效的体内中性大麻素CB1受体拮抗剂。LH-21 可以减少肥胖 Zucker 大鼠的食物摄入和体重增加。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jagerovic, N., Hernandez-Folgado, L., Alkorta, I., et al.Discovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motifJ. Med. Chem.47,2939-2942(2004)
Pavon, F.J., Bilbao, A., Hernández-Folgado, L., et al.Antiobesity effects of the novel neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole - LH 21Neuropharmacology51,358-366(2006)
Pavón, F.J., Serrano, A., Pérez-Valero, V., et al.Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: Effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker ratsJ. Neuroendocrinol.20,116-123(2008)
Chen, R.Z., Frassetto, A., Lao, J.Z., et al.Pharmacological evaluation of LH-12, a newly discovered molecule that binds to cannabinoid CB1 receptorEur. J. Pharmacol.584,338-342(2008)
