JLK-6
Cat. No.：YN380399
| 产品名称: | JLK-6 |
| CAS No.: | 62252-26-0 |
| Chemical Name: | 7-amino-4-chloro-3-methoxy-1H-2-benzopyran-1-one |
| Synonyms: | JCP251|JCP-251;JCP 251 |
| 分子量: | 225.62816 |
| 分子式: | C10H8ClNO3 |
| SMILES: | NC1=CC=C2C(C(OC(OC)=C2Cl)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JLK-6 通过影响表达HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解APP，显著减少了 Aβ的产生，而不影响Notch受体的裂解。 |
| IC50和靶点: | |
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Harper, J.W., and Powers, P.C.3-Alkoxy-7-amino-4-chloroisocoumarins: A new class of suicide substrates for serine proteasesJ. Am. Chem. Soc.106(24),7618-7619(1984)
Bihel, F., Quéléver, G., Lelouard, H., et al.Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of proteaseBioorg. Med. Chem.11(14),3141-3152(2003)
Petit, P., Pasini, A., da Costa, C.A., et al.JLK isocoumarin inhibitors: Selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivoJ. Neurosci. Res.74(3),370-377(2003)
