MK-0812
Cat. No.：YN322576
| 产品名称: | MK-0812 |
| CAS No.: | 624733-88-6 |
| Chemical Name: | 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)- 3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol |
| Synonyms: | MK-0812,MK 0812 |
| 分子量: | 469.5 |
| 分子式: | C24H34F3N3O3 |
| SMILES: | O=C([C@@]1(C(C)C)CC[C@@H](N[C@]2([H])[C@H](OC)COCC2)C1)N(C3)CCC4=C3C=C(C(F)(F)F)C=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-0812 是一种有效的选择性的CCR2拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Abagyan, R., Christopoulos, A., de Esch, I.J.P., et al.Chemokines. Chemokines and their receptors in drug discovery,1-248(2015)
Zhang, F., Li, P., Liu, S., et al.β-Catenin-CCL2 feedback loop mediates crosstalk between cancer cells and macrophages that regulates breast cancer stem cellsOncogene40(39),5854-5865(2021)
Min, S.-H., Wang, Y., Gonsiorek, W., et al.Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritisBiochem. Biophys. Res. Commun.391(1),1080-1086(2010)
