KM-233
Cat. No.：YN322579
| 产品名称: | KM-233 |
| CAS No.: | 628263-22-9 |
| Chemical Name: | 6aR,7,10,10aR-tetrahydro-6,6,9-trimethyl-3-(1-methyl-1-phenylethyl)-6H-dibenzo[b,d]pyran-1-ol |
| Synonyms: | |
| 分子量: | 362.5 |
| 分子式: | C25H30O2 |
| SMILES: | CC(C1=CC=CC=C1)(C)C2=CC(O)=C3C(OC(C)(C)[C@H]4[C@H]3CC(C)=CC4)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KM-233 是一种典型的大麻素，具有良好的血脑屏障穿透性。KM-233 对CB2受体具有相对于 THC 的选择性亲和性。KM-233 能有效降低 U87 胶质瘤的肿瘤负担，可用于胶质瘤的研究。 |
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Sánchez, C., de Ceballos, M.L., Gomez de Pulgar, T., et al.Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptorCancer Res.61(15),5784-5789(2001)
Krishnamurthy, M., Ferreira, A.M., and Moore, B.M., IISynthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoidsBioorg. Med. Chem. Lett.13(20),3487-3490(2003)
Duntsch, C., Divi, M.K., Jones, T., et al.Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade gliomaJ. Neurooncol.77,143-152(2006)
