AH-7614
Cat. No.：YN322582
CAS No. ：6326-06-3
| 产品名称: | AH-7614 |
| CAS No.: | 6326-06-3 |
| Chemical Name: | 4-methyl-N-9H-xanthen-9-yl-benzenesulfonamide |
| Synonyms: | Benzenesulfonamide,4-methyl-N-9H-xanthen-9-yl-;AH 7614;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;4-methyl-N-9H-xanthen-9-yl-Benzamide;N-(9-xanthyl)-4-toluensulfonamide;N-(9-Xanthyl)-p-toluamid;N-(9-xanthyl)-p-toluensulfonamide;N-xanthen-9-yl-p-tolua |
| 分子量: | 351.4 |
| 分子式: | C20H17NO3S |
| SMILES: | CC1=CC=C(S(NC2C(C=CC=C3)=C3OC4=C2C=CC=C4)(=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AH-7614 是一种有效和选择性的FFA4 (GPR120)拮抗剂，对人，小鼠和大鼠 FFA4 的pIC50值分别为 7.1，8.1 和 8.1。AH-7614 对 FFA4 的选择性高于 FFA1 (pIC50<4.6)。AH-7614 能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Davenport, A.P., Alexander, S.P.H., Sharman, J.L., et al.International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligandsPharmacol. Rev.65(3),967-986(2013)
Oh, D.Y., Talukdar, S., Bae, E.J., et al.GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effectsCell142(5),687-698(2010)
Sparks, S.M., Chen, G., Collins, J.L., et al.Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)Bioorg. Med. Chem. Lett.24,3100-3103(2014)
